Product Description
Overview
Uridine is one of the key nucleotide that making RNA. It is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring[or more specifically, a ribofuranose] via a β-N1-glycosidic bond. It is one of the five standard nucleosides which make up nucleic acids[including both RNA and DNA] with the others four being adenosine, thymidine, cytidine and guanosine. The five nucleosides are commonly abbreviated to their one-letter codes U, A, T, C and G respectively. Thymidine is found in deoxyribonucleic acid[DNA] and not ribonucleic acid(RNA]. Conversely, uridine is found in RNA and not DNA. The remaining three nucleosides can be found in both RNA and DNA. In RNA, they would be represented as A, C and G whereas in DNA they would be represented as dA, dC and dG.
Biosynthesis and source
Uridine is widely produced in the form of uridine monophosphate[uridylate] through the decarboxylation of orotidylate, being catalyzed by orotidylate decarboxylase. The orotidylate is produced from orotate, which is combined with 5-phosphoribosyl-1-pyrophosphate[PRPP] to form orotidylate by pyrimidine phosphoribosyltransferase. PRPP is created from ribose-5-phosphate by a further phosphorylation, serving as an energetic molecule to drive the reaction forward, while orotate is generated in several steps from carbamoyl phosphate and aspartate.
Diet is not an important source of uridine. Clinical studies and animal experimentation suggest that the liver synthesizes and degrades uridine, and is likely to have a central role in maintaining plasma uridine. Blood platelets and storage organelles of various species are reported to contain UTP and may provide releasable pools of uridine after catabolism.
Applications
Uridine is phosphorylated to nucleotides, which are used for DNA and RNA synthesis as well as for the synthesis of membrane constituents and glycosylation. Uridine plays a very important role in the glycolysis pathway of galactose. It can be used as a precursor in the production of CDP-choline. It is an important nutrient and widely used as a dietary supplement. It can improve the brain cholinergic functions and hepatic mitochondrial function in certain liver toxins. It plays a major role in pain physiology and brain energy utilization to maintain ATP production under restricted oxygen conditions. Uridine has many biological effects and, is thus can be used for the treatment of various kinds of diseases. In general, uridine can be used for the treatment for the following diseases such as cardiovascular disease and hypertension, respiratory dysfunction, liver disease, infertility, epilepsy, cancer & AIDS, Parkinsonism, anxiety, sleep dysfunction and Ischemia and hypoxia.
Uridine plays a crucial role in the pyrimidine metabolism of the brain. It supplies nervous tissue with the pyrimidine ring, and in turn, participates in a number of important metabolic pathways. Uridine and its nucleotide derivatives may also have an additional role in the function of the central nervous system as signaling molecules. Uridine administration had sleep-promoting and anti-epileptic actions, improved memory function and affected neuronal plasticity. Uridine can exert various kinds of effects on the central nerve system[CNS] It was found to be an active component of sleep-promoting substances in our brain Anti-epileptogenic and anti-convulsant effect Thermoregulatory effect long-term exposure to uridine improve our memory involved in the regulation of neuronal plasticity through for example that it enhances neurite outgrowth. Based on those above findings, it can be used for the treatment of various diseases such as developmental delay, seizures, ataxia, severe language deficit, age-related cognitive decline and even Alzheimer's disease and Parkinson's disease. Uridine might also be useful as a nutrition supplement during development. Uridine[as uridine monophosphate] is found in mother's milk and has been proposed to play a role in regulatory mechanism through which plasma composition influences brain development.
Packaging & Shipping
Packing:25kg/fiber drum.we also can provide 1kg
Shipping:by express DHL,FEDEX,TNT......or as your requirement
Payment:T/T,western union,moneygram or as your requirement
Company Profile
Dalian Sinobio Chemistry Co.,Ltd_was established in 2011 and located in beautiful costal city Dailan Liaoning Province. we can enjoy convenient transportation by all logistic ways. Sinobio cooperated with Dalian university of technology, who has 2 production sites: one located in Lanzhou city , Gan Su province who mainly produce biocides and pharmaceutical related. Another located in Fuzhou city,Jiangxi province .It was founded in 2013 with abundant financial resources.
As a professional agrochemical and it's intermediates products' supplier, they have excellent teams who focus on product development & design, quality control & inspection and company running. In order to supply the qualified products and services, we have built a modern quality management system which is in strict accordance with international standards. Our factory has got ISO9001&ISO14001 certificates.
Adhering to the business principle of mutual benefits, we have had a good reputation among our customers because of our perfect services, quality products and competitive prices. We warmly welcome customers from at home and abroad to cooperate with us for common success.
Certifications
Our Advantages
Our promise:Reply with 2 hours.
1) Focus on chemical products export over 16+ years.
2) We commit Sample quality = Batch quality.
3) Professional sales 24 hours on line with Mail / Whatsapp / Wechat / Linkin / Twitter /Made in China
4) Once inquiry. Get all your Needed chemical raw materials.
FAQ
Q1: Can I get samples?
A: Yes, we can supply free sample, you pay for the freight charge only.
Q2: How to pay?
A: PI will be sent firstly after our aligned products specification. Payment by Paypal , T/T, Western Union,LC
Q3: How is your MOQ?
A: Normally speaking, our MOQ is 1kg. But we can also accept less quantity such as 100g on the condition that sample charge is100% paid.
Q4: How can you guarantee the quality of your products?
1. Our staff are all experienced in chemical products or related major background, they are well trained before quotation.
2. Free sample or pre-shipment sample are available for our new cooperation before you place commercial order. We are sure the same specification commercial products as sample to customers
3. Third Party Inspection like SGS can be arranged according to your requirement before shipping.
4. On-Spot QC in our APPROVED associated production bases with necessary certification like GMP, ISO etc.
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