| Customization: | Available |
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| CAS No.: | 70288-86-7 |
| Formula: | C95h146o28 |
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Ivermectin is a new broad-spectrum, high-efficiency, low-toxicity antibiotic antiparasitic drug, which has a good killing effect on internal and external parasites, especially nematodes and arthropods. But it is ineffective against tapeworms, flukes and protozoa. The repelling effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the release of the inhibitory transmitter γ-aminobutyric acid (GABA) of the worms, and to open the Cl ion channel controlled by glutamate, Enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, eventually nerve paralysis, so that muscle cells lose the ability to contract, resulting in the death of the worm.
Indications of function
This product is a derivative of avermectin, which is an oral semi-synthetic broad-spectrum antiparasitic drug. This product is effective against most (but not all) nematodes of various life cycles; it is effective against microfilariae of Onchocerciasis, but not adults; it is also effective against strongyloides only in the intestinal tract. This product has a selective inhibitory effect. It binds with high affinity to chloride ion channels with glutamate as the valve in nerve cells and muscle cells of non-vertebral animals, resulting in an increase in the permeability of cell membranes to chloride ions, causing nerve cells or muscles. The cells hyperpolarize, paralyzing or dying the parasite. It also interacts with chloride channels of other ligand valves, such as the neurotransmitter g-aminobutyric acid (GABA). The selectivity of this product is due to the absence of glutamate-chloride channels in some mammals and the low affinity of abamectin for mammalian ligand-chloride channels. This product cannot penetrate the human blood-brain barrier. Onchocerciasis and strongyloidiasis and hookworm, roundworm, whipworm, pinworm infection.
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Product Name
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Ivermectin | |
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Cas No.:
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70288-86-7 | |
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EINECS No
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274-536-0 | |
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Reference
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USP | |
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Test Item
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Specification.EP
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Test results
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Appearance
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White or yellowish-white crystalline powder
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White-crystalline powder
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Appearance of solution
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The solution is clear and not more intensely
Coloured than reference solution BY7
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Clear
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Identification IR HPLC |
Corresponds with that of CRS standard
The retention time for H2B1a and H2B1b
Corresponds to CRS
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Complies
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Water
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Not more than 1.0%
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0.15
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Ethanol
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Not more than 5.0%
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3.3
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Formamide
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Not more than 3.0%
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2.0
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Ratio H2B1a /(H2B1a+ H2B1b),a
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Not less than 90.0%
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95.2
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Assay(H2B1a+ H2B1b)
(anhydrous and solvent-free substance)
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95.0%~102..0%
Between95.0% and 102.0%
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97.5 |
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Related compounds
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1:Theindividual impurity(RRT1.3-1.5),Not more than 2.5%
2:Any other individual impurity not more than 1% 3:Sum of total impurities not more than 5%
4:Disregard peaks less than 0.05%
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1:1.50 2:0.50 3:2.1 4:0.05 |
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Heavy metals
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Not more than 20ppm
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<20ppm
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Sulphated ash
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Not more than 0.1%
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<0.07
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Specific optical rotation(anhydrous and
solvent-free substance)
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Between-17o--20o
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-19o
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Residual solvents
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Not more than 890ppm
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<890ppm
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Conclusion
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Complies with the requirement of USP
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Packing: 25kgs Drum
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