| Customization: | Available |
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| CAS No.: | 70288-86-7 |
| Formula: | C95h146o28 |
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Ivermectin is a new broad-spectrum, high-efficiency, low-toxicity antibiotic antiparasitic drug, which has a good killing effect on internal and external parasites, especially nematodes and arthropods. But it is ineffective against tapeworms, flukes and protozoa. The repelling effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the release of the inhibitory transmitter γ-aminobutyric acid (GABA) of the worms, and to open the Cl ion channel controlled by glutamate, Enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, eventually nerve paralysis, so that muscle cells lose the ability to contract, resulting in the death of the worm.
Indications of function
This product is a derivative of avermectin, which is an oral semi-synthetic broad-spectrum antiparasitic drug. This product is effective against most (but not all) nematodes of various life cycles; it is effective against microfilariae of Onchocerciasis, but not adults; it is also effective against strongyloides only in the intestinal tract. This product has a selective inhibitory effect. It binds with high affinity to chloride ion channels with glutamate as the valve in nerve cells and muscle cells of non-vertebral animals, resulting in an increase in the permeability of cell membranes to chloride ions, causing nerve cells or muscles. The cells hyperpolarize, paralyzing or dying the parasite. It also interacts with chloride channels of other ligand valves, such as the neurotransmitter g-aminobutyric acid (GABA). The selectivity of this product is due to the absence of glutamate-chloride channels in some mammals and the low affinity of abamectin for mammalian ligand-chloride channels. This product cannot penetrate the human blood-brain barrier. Onchocerciasis and strongyloidiasis and hookworm, roundworm, whipworm, pinworm infection.
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Product Name
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Ivermectin | |
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Cas No.:
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70288-86-7 | |
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EINECS No
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274-536-0 | |
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Reference
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USP | |
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Test Item
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Specification.EP
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Test results
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Appearance
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White or yellowish-white crystalline powder
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White-crystalline powder
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Appearance of solution
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The solution is clear and not more intensely
Coloured than reference solution BY7
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Clear
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Identification IR HPLC |
Corresponds with that of CRS standard
The retention time for H2B1a and H2B1b
Corresponds to CRS
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Complies
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Water
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Not more than 1.0%
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0.15
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Ethanol
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Not more than 5.0%
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3.3
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Formamide
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Not more than 3.0%
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2.0
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Ratio H2B1a /(H2B1a+ H2B1b),a
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Not less than 90.0%
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95.2
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Assay(H2B1a+ H2B1b)
(anhydrous and solvent-free substance)
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95.0%~102..0%
Between95.0% and 102.0%
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97.5 |
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Related compounds
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1:Theindividual impurity(RRT1.3-1.5),Not more than 2.5%
2:Any other individual impurity not more than 1% 3:Sum of total impurities not more than 5%
4:Disregard peaks less than 0.05%
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1:1.50 2:0.50 3:2.1 4:0.05 |
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Heavy metals
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Not more than 20ppm
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<20ppm
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Sulphated ash
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Not more than 0.1%
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<0.07
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Specific optical rotation(anhydrous and
solvent-free substance)
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Between-17o--20o
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-19o
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Residual solvents
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Not more than 890ppm
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<890ppm
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Conclusion
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Complies with the requirement of USP
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Packing: 25kgs Drum.
Shipping: by sea,by air,by express DHL,FEDEX,TNT......or as your requirement.
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Dalian Sinobio Chemistry Co.,Ltd_was established in 2011 and located in beautiful costal city Dailan Liaoning Province. we can enjoy convenient transportation by all logistic ways. Sinobio cooperated with Dalian university of technology, who has 2 production sites: one located in Lanzhou city , Gan Su province who mainly produce biocides and pharmaceutical related. Another located in Fuzhou city,Jiangxi province .It was founded in 2013 with abundant financial resources.
As a professional agrochemical and it's intermediates products' supplier, they have excellent teams who focus on product development & design, quality control & inspection and company running. In order to supply the qualified products and services, we have built a modern quality management system which is in strict accordance with international standards. Our factory has got ISO9001&ISO14001 certificates.
Adhering to the business principle of mutual benefits, we have had a good reputation among our customers because of our perfect services, quality products and competitive prices. We warmly welcome customers from at home and abroad to cooperate with us for common success.
Our promise:Reply with 2 hours.
1) Focus on chemical products export over 16+ years.
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Q1: Can I get samples?
A: Yes, we can supply free sample, you pay for the freight charge only.
Q2: How to pay?
A: PI will be sent firstly after our aligned products specification. Payment by T/T,LC.
Q3: How is your MOQ?
A: Normally speaking, our MOQ is 1kg. But we can also accept less quantity such as 100g on the condition that sample charge is100% paid.
Q4: How can you guarantee the quality of your products?
1. Our staff are all experienced in chemical products or related major background, they are well trained before quotation.
2. Free sample or pre-shipment sample are available for our new cooperation before you place commercial order. We are sure the same specification commercial products as sample to customers
3. Third Party Inspection like SGS can be arranged according to your requirement before shipping.
4. On-Spot QC in our APPROVED associated production bases with necessary certification like GMP, ISO etc.
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